Medium Composition Effect On Coenzyme Q Production By Metabolic Engineered Escherichia Coli Strains
Coenzyme Q (CoQ) applications have increased significantly in the past few years. Then, there is a strong interest in developing better production systems and processes. In the present work, the use of metabolically modified Escherichia coli was evaluated using different culture media for the accumulation of CoQ. The results showed that glycerol and succinate significantly increased CoQ accumulation in the control and modified E. coli strains in comparison to glucose, with glycerol showing the highest productivity in both strains.
Index Terms - coenzyme Q, Escherichia coli, metabolic engineering, ubiquinone