Is Bone Mineral Density A Risk Factor of Breast Cancer in Premenopausal Women?
The objective of the study was to determine the association between bone mineral density and other risk factors of breast cancer in premenopausal women.A cross-sectional study was done for aduration of six months. Apurposive sampling was used and a total of 37 premenopausal Malaysian women underwent both Dual Energy X-ray Absorptiometry (DEXA) and mammography. The mean of selected characteristics were compared with four different breast densitiesand normal and abnormal BMD using ANOVA and chi-square test respectively. Binomial logistic regression was used to determine the association of BMD with the risk factors of BC. Mean age of the participants was 47 (±4) years old. A total of 27 women had normal BMD 33 had scattered fibroglandular or heterogenously dense breast.Mean BMD T-scores in hip region was0.416 (±1.3) whilst mean score in lumbar spine was0.065 (±1.4). Higher number of older women hadosteopenia with lower BMI and had a later menarche age. There was no significant association between BMD, MBD andthe risk factors of BC among the premenopausal women. However descriptive analysis showed older women had osteopenia with lower BMI.
Key words- Bone mineral density(BMD), Mammographic breast density (MBD), Breast cancer (BC), Risk factor