Expressions And Clinical Significance Of CXCR7, MTDH And RRM1 In Basal-Like Breast Carcinoma
Objective To explore the expressions and clinical significances of the chemokine receptor 7 (CXCR7) , metadherin (MTDH), and ribonucleotide reductase M1(RRM1) in basal-like breast carcinoma(BLBC). Methods The tissues of breast cancer excised in the operations were collected and divided into three groups: BLBC (n=46), nonBLBC (n=46), and para-carcinoma tissues (n=46). The expressions of the CXCR7, MTDH, and RRM1 in BLBC , nonBLBC, and para-carcinoma tissues were detected by using immunohistochemistry . The relationships of the CXCR7, MTDH, and RRM1 expressions in the BLBC tissues and clinicpatho-logical features were analyzed. Results The expressions ratio of the CXCR7, MTDH, and RRM1 in BLBC tissues were 71.7%, 58.7%, and 41.3%, respectively. In the non BLBC tissues they were 65.2%, 50%, and 47.8%, respectively. The expressions of CXCR7 and MTDH in cancerous tissues had no difference(P>0.05). The expressions ratio of CXCR7, MTDH, and RRM1 in the para-carcinoma tissues were 15.2%, 10.9%, and 19.6%, respectively. There was significant difference between normal and cancerous tissues (P<0.01). In the BLBC, the expressions of CXCR7 and MTDH had positive correlations with lymph node metastasis and TNM stage, rather than age, menopause, and tumor size. The expression of RRM1 had no relation with age, tumor size, lymph node metastasis, menopause, and TNM stage. Conclusions The CXCR7, MTDH, and RRM1 highly expressed in BLBC tissues. They may play important roles in the occurrence and progress of BLBC and related closely with lymph node metastasis. To Detect the CXCR7 and MTDH could be helpful in the diagnosis and prediction of the prognosis of BLBC.
Index Terms- Basal-Like Breast Carcinoma (BLBC); Chemokine Receptor 7 (CXCR7); Metadherin (MTDH); Ribonucleotide Reductase M1(RRM1).