Exploring The Effect of Thymoquinone on Neuropsychological Impairment in Experimentally Induced Fibromyalgia
In the present investigation, the effect of thymoquinone on neuropsychological impairment in reserpine induced fibromyalgia has been explored. Fibromyalgia was induced by the administration of 1 mg/kg reserpine to mice for 3 consecutive days. The effect of thymoquinone (10 and 20 mg/Kg) on fibromyalgia was explored. Fibromyalgia was evaluated by using different models such as Eddy’s hot plate test, tail immersion test for evaluating hyperalgesia; forced swim test for depression; inclined plane test for evaluating motor activities and Morris water maze, elevated plus maze test for evaluating acquisition and retention of memory using standard methods. Reserpine administration was found to mimic the effects and symptoms of fibromyalgia. Maximum effect was evident on day 4 and 6 of reserpine treatment as observed by an increase in thermal hyperalgesia, depression, impaired motor- coordination and memory. Pretreatment with the standard drug duloxetine and thymoquinone was found to significantly attenuate reserpine effect in neuropsychological impairment in reserpine induced fibromyalgia from day 2 to 5. However on 5th day of treatment there was 100% mortality in both the treatment groups. The results of study indicate that thymoquinone does not produce any protection in reserpine induced fibromyalgia.
Keywords - Fibromyalgia, Pain Reserpine, Thymoquinone