Paper Title
Evaluation Of The Effect Of Levetiracetam On Wound Healing By Excision And Burn Wound Models In Wistar Rats

Abstract
Introduction Oxidative stress inhibits angiogenesis, reduces endothelial function, and generates superoxide’s that cause impairment in wound healing. Levetiracetam at lower doses (50 and 100 µg/ml), have demonstrated antioxidant effect as per literature evidence. Hence aim of current study was to evaluate the action of levetiracetam on wound healing with regards to its anti-oxidant properties. Materials and Methods 30 Adult rats of both sexes weighing 150 to 250 g were randomly divided into 5 groups of 6 rats each. Excision and burn models were used. Group 1: Normal saline, Group 2: Povidone Iodine, Group 3: Silver Sulphadiazine, Group 4: Levetiracetam 50 mg/kg, Group 5: Levetiracetam 100mg/kg. Group 2 served as standard control for excision wound model and group 3 as standard for burn wound model. Levetiracetam was given orally and all other drugs were given topically. The rate of wound contracture and period of epithelization were calculated from the initial wound size for all rats. Statistical analysis was done using One way ANOVA and followed by Post-Hoc test with p value of 0.05 or less considered significant. Results In both the models, the rats treated with standard drug (povidone iodine/ silver sulphadiazine) and levetiracetam showed faster rates of wound contraction as well as period of epithelization as compared to the control and the difference seen was statistically significant (p < 0.001). However, the rats treated with povidone iodine/ silver sulfadiazine showed faster rates of wound contraction and period of epithelization as compared to the rats treated with levetiracetam and was statistically significant (p<0.05). Conclusion The results of the study show that oral application of Levetiracetam enhanced wound strength and accelerated healing of incision and burn wounds in rats. Furthur clinical trials can be done to prove the effect of levatiracetem as an agent for wound healing.