Paper Title
A Global Treat of Autism Spectrum Disorder Phenotypes Caused by Prenatal and Postnatal Lyme Borreliosis Transmittet by Genus Ixodes Ticks

Abstract
Autism Spectrum Disorder (ASD) is one of the most prevailing neurodevelopmental disorders characterized by impaired social interaction, communication deficits, and the presence of repetitive, restricted behavioral patterns and interests. It occurs due to the mutations related to the development and proper function of the neurons, combined with the impact of various epigenetic environmental factors. Ixodes ticks are a growing treat with strong epidemiological significance being the vector of Lyme borreliosis caused by the spirochetes of genus Borrelia. Borreliosis has been reported to be characterized by neurological symptoms that overlap those of ASD, thus being one of the preventative causes of deteriorations in development. We performed a survey in a cohort of 62 Bulgarian children having a diagnose ASD and their families in order to assess the probability of Lyme borreliosis to be a background of developmental disorders in the autism spectrum. We detected a case of a child with ASD born by a mother that underwent borreliosis infection during pregnancy, and another case of a child with ASD and borreliosis. Our findings confirm the hypotheses of the Borrelia burgdorferi implication as an epigenetic factor intricated in autism pathogenesis. Prevention and timely treatment of borreliosis will decrease the risk of ASD development in children. Keywords - Area-Efficient, Low Power, CSLA, Binary to Excess one Converter, Multiplexer.