Paper Title
Serum IL-33 Level in Pregnant Women Experienced Miscarriage With / Without Toxoplasmosis.

Abstract
Introduction: Successful pregnancy is related tosafe immunotransitionfrom Th1 to Th2 immune response.Toxoplasmosis is a major cause of miscarriage. IL-33 is related to miscarriage and parasitic infection. Aim: this study aims to investigate seropositivity status of IL-33 inpregnant women with/without toxoplasmosis, with miscarriage cases in first trimester of pregnancy. Materials and Methods: this study implies a case- control design. Forty four blood samples were collected from pregnant women experienced miscarriage and 36 samples from another group with healthy pregnancy as control group. Toxoplasma gonidii was qualitatively and IL-33 was quantitatively detected by Enzyme linked Immunosorbent assay (ELISA), clinical symptoms were collected by the physicians. Results: T. gonidiiwas detected in (15.9%) of pregnant women with miscarriage, and in in (13.8%) in control group, with no significant difference between the two groups.IL-33 concentration showed significant difference among healthy pregnant women positive for anti- T. gonidii IgG antibodies and those negative anti- T. gonidii IgG antibodies, P-value0.002. also ,IL-33 concentration showed significant difference between healthy pregnant women negative for anti- T. gonidii IgG antibodies and those with miscarriage and negative for anti- T. gonidii IgG antibodies, P-value0.008. Conclusion: Disruption in serum IL-33 is contributed with miscarriage and with toxoplasmosis. Such finding may pave the way to imply IL-33 based treatment to control pregnancy failure. Keywords - Toxoplasmosis, IL-33, Miscarriage