Paper Title
HYBRID NANOMATERIALS BASED ON Β-CYCLODEXTRINS AND THEIR APPLICATION IN POCT TESTS

Abstract
PROBLEM STATEMENT Point-of-care glucose meters (POCT) often have variable accuracy due to differences in user technique, environmental conditions, and device calibration, which can lead to misinterpretation of blood glucose levels. This inconsistency poses risks to patient safety and complicates clinical decision making and the need for new biosensor devices [1,2]. METHODS The hybrid nanomaterial was characterised using physicochemical methods (electrokinetic potential, TEM, AFM, andBrodford method) and electrochemical techniques (cyclic voltammetry, chronoamperometry). Results RESULTS β-cyclodextrins-based hybrid nanomaterial based on -cyclodextrinswas proposed as a matrix to immobilise the enzyme glucose oxidase, ultimately leading to the construction of an enzymatic biosensor. This system utilizes screen-printed electrodes (SPE). The proposed setup was integrated with the world's smallest potentiostat and designed to work in conjunction with portable devices like smartphones or tablets. The system also demonstrated strong selectivity against various interfering agents, enabling its application to real glucose solutions like human blood and human serum. The biosensor exhibited long-term stability, maintaining functionality for up to 11 months. An important aspect is that this biosensor adheres to the latest FDA regulationsregarding the design of new glucometers. CONCLUSION The presented biosensor shows a compelling option as a mobile point-of-care testing device for glucose measurements. ACKNOWLEDGMENTS The work was financed and prepared by the Poznan University of Technology research grant no. 0912/SBAD/2411.