Paper Title
SPECIFIC THERAPY FOR PANCREATIC CANCER INVOLVING THE UTILIZATION OF DENDRITIC STEM CELLS AND GOLD NANOPARTICLES THAT HAVE BEEN MODIFIED WITH CA-19-9

Abstract
Pancreatic cancer (PC) is regarded as the most lethal form of human malignancy and represents a significant global health concern. Given its intrinsic resistance to chemotherapeutics, PC exhibits high mortality rates and low survival rates. In our current research, we have developed a unique nanostructured model for a pancreatic therapy. This model is based on a nano-biosystem composed of 25 nm gold nanoparticles that are conjugated to CA 19-9 epitopes. Through the use of proteomic analysis, immunocytochemistry, flow cytometry, and hyperspectral microscopy, we have demonstrated that the CA-19-9-GNPs nanobioconjugate can effectively contribute to an optimal prophylactic effect against PC. This is achieved through the promotion of major histocompatibility complex (MHC) mediated antigen presentation by dendritic cells. Given that this approach enhances the recognition of tumoral antigens by the immune system, we can conclude that the proposed immunoprophylactic strategy may prove to be more effective than the current treatments for PC. Keywords - Gold Nanoparticles, Pancreatic Cancer, Dendritic Cells.