Paper Title
Anti-Inflammatory Effects of Polysaccharides From Some Lactobacillus Species

Abstract
This study has shown that the treatment withthe Lactobacilli polysaccharides could suppress ear edema in the mice sensitized with DNFB. In addition, the secreted levels of TNF (pro-inflammatory cytokines) and IL-10 (an anti-inflammatory one) were determined by using macrophagecell line, matured THP-1 cells. Our results showed that the treatment by the polysaccharide fractions from Lactobacillus caseiand gasseri, respectively, could inhibit the secretion of TNF and promote the IL-10 production after the LPS/IFN activation of the macrophages.That effect of the polysaccharide from L. casei was stronger than that from L. gasseri. These results suggest that the lactobacilli polysaccharides significantly could modulate the capacity of naïve macrophages to grow out to an anti-inflammatory macrophage subtype.The current study suggests that the lactobacilli polysaccharides from not only L. casei also L. gasseri could modulate the capacity of naïve macrophages to grow up to an anti-inflammatory macrophage subtype. Therefore, a treatment with the lactobacilli polysaccharides mightcontribute to amelioration in inflammatory diseases. Keywords - Allergic Contact Dermatitis, Anti-Inflammation, Lactobacillus Polysaccharide, M2 Macrophages