Paper Title
Development of A Peptide Conjugated Neural Guidance Channel Made of Electrospun Nanofibers To Enhance Vascularization During Nerve Regeneration

Vascularization is crucial for nerve regeneration as it facilitates the delivery of oxygen, nutrients, and growth factors essential for tissue repair and the formation of functional neural networks.Here, a novel synthetic nerve guidance channel (F-SNGC) was developed to enhance vascularization during nerve regeneration. First, a SNGC was made of aligned poly(lactic-co-glycolic acid) (PLGA) nanofibers via electrospinning and then functionalized with a short bioactive peptide YIGSR (LM-BP) known to induce vascularization. The vascularization of HUVEC cells in F-SNGC was characterized by live and dead imaging and PCR. The results clearly show that the conjugated LM-BPsignificantly accelerated vascularization by inducing the differentiation of HUVEC cells in F-SNGCs. Based on the results, the present innovative approachis believed to hold great potential in achieving the intricate coordination between nerve growth and blood vessel formation to establish functional connections and support tissue repair. Keywords - Nerve guide channels, Bioactive peptide, Electrospinning, Graft, Peripheral nerve injury.