Paper Title
AGAINST THE WAVES OF EVOLUTION: A NEW APPROACH FOR INTRINSIC IMMUNITY CREATION

Abstract
Evolution is the main force for diversity and survival of species. Obviously, we would just not exist without its natural selection pressure but along with its numerous advantages there are a few disadvantages, and one of them is our being prone to certain diseases. One of the clear examples is the possibility of zoonotic disease. As we have evolved from common ancestors along with the other mammals, we have very similar body proteins especially in our regulatory system. The hot spot is a cell membrane receptor and a signalling pathway network. The receptor is used by pathogens for endocytosis so its structural similarity with the other mammals’ one puts us in danger of novel zoonotic diseases. The structural change of the receptor is very logical solution, but it is necessary to change also its ligands and their other receptors and ligands and so on. The complexity rises in geometric progression. The example of the famous ACE2 receptor will provide a brief understanding of the principle of the possible intrinsic immunity and complexity of the system. Also, a brief overview of computational solutions and possibilities such as DB, MD simulators and their current state will be provided.As a conclusion, the evolutional disadvantage can technically be resolved using current wet lab technology but there are lots of pitfalls to overcome. Ethical issues of working on human material can be solved to some extent by computational methods but the system complexity creates the need for new software solutions focused on a signal molecule’s whole network. Keywords - Intrinsic Immunity, Zoonotic Disease, Signalling Pathways, ACE2 Receptor, Evolutionary Receptor Similarity