Paper Title
ASSESSMENT OF COAGULATION PROFILE IN SICKLE CELL DISORDERS IN JAZAN REGION

Abstract
Statement of the Problem: Sickle cell disease (SCD) is one of the most widely common genetically disorders, which is representative with a wide clinical severity. (Weatherall, 2005)In Saudi Arabia, SCA is reported with a high prevalence rate in Jazan provinces. (Moody et al., 2019)SCD is commonly considered a hypercoagulation state, as the patients of SCD mostly have altered hemostatic components, which may lead to an increased risk of thrombosis complications. (Ogunsile, Naik and Lanzkron, 2019) previous studies have been considered to demonstrate that the excessive activity of blood clotting factors in patients with sickle cell anemia may play an important role in disease progression. (Pakbaz and Wun., 2014)(Brunson et al., 2017) The purpose of this study is to evaluate the Coagulation profile patterns and hematological characteristics in SCD patients from the Jazan region of Saudi. Methodology:One hundred fifty participants were recruited for this research, consisting of 50 Sickle cell anemia patients, 50 sickle cell trait subjects with HbAS and 50 healthy subjects with hemoglobin AA were recruited for the current cross-sectional study. Following informed consent, 5 mL of two venous blood samples were collected to investigate their routine coagulation profile involving PT, PTT and hematological test. Findings:Thecoagulation profile results show that PT and PT levels were significantly different (p less than 0.05) in SCA patients with HbSS compared to the healthy control group. However, there were non-significant differences (p greater than 0.05) in the levels of PTT and PT between Sickle cell trait HbAS and the healthy controls. Conclusion: The study findings concluded that patients with SCD tend to have abnormal coagulation activation as they should receive health education regarding their general health status for further evaluation and treatment. Image1:Result of coagulation tests of control group and case group (HbSS and HbAS) Keywords - Sickle Cell Anemia, Coagulation, Hemoglobin, Jazan, and Saudi Arabia.