Paper Title
DIETARY BIOACTIVE COMPOUNDS FOR NEUROPATHIC PAIN: CURRENT PRECLINICAL FINDINGS AND FUTURE DIRECTION

Abstract
Abstract - Chronic pain is a complex disorder that impacts quality of life and represents a critical health care problem. Among different types of chronic pain, neuropathic pain, arising from damage to the nervous system, including peripheral fibers and central neurons, is notoriously difficult to treat and affects 7-10% of the general population. Currently available treatment options for neuropathic pain are limited and opioid analgesics have severe side effects and can result in opioid use disorder. The goals of treatment are to mitigate pain, restore the function of peripheral fibers and central neurons, and minimize the disabling effects of the disease. Recent studies have shown an association between diet-derived bioactive compounds with anti-inflammatory and anti-oxidant properties and the reduction of neuropathic pain-related inflammation. This presentation will cover the following (i) overview of prevalence and etiology of neuropathic pain, (ii) findings of commonly consumed plant-derived nutrients or bioactive compounds, for example ginger root extract and its bioactive compounds, on neuropathic pain in animal pain models, (iii) possible molecular anti-neuropathic pain mechanisms, and (iv) challenges, limitation, and future direction.