Paper Title
THE RELATIONSHIP BETWEEN GUT MICROBIOTA AND DIETARY HABITS IN PREDIABETIC PATIENTS: AN ANALYSIS OF FAT INTAKE AND BACTERIAL EXPRESSION

Abstract
Abstract - In recent years, the prevalence of diabetes has been continuously increasing due to changes in lifestyle and dietary habits. Most patients experience "prediabetes" before being diagnosed with diabetes. Previous studies have indicated that poor dietary habits can alter the gut microbiota and contribute to the development of diabetes. However, the relationship between gut microbiota changes in prediabetic patients and their dietary habits has not been explored.In this study, 57 prediabetic patients were recruited from Taipei Tzu Chi Hospital. Patients who had used probiotics and antibiotics in the past 8 weeks were excluded. Patients had fasting blood glucose levels of 100-126 mg/dl and glycosylated hemoglobin levels of 5.7-6.4%. Twenty-four-hour dietary records and stool samples were collected to analyze the relationship between their gut microbiota and dietary habits.Analysis of fat intake showed significant differences between the high-fat group and the low-fat group in "monoterpenoid biosynthesis" (ko00902), "morphine addiction" (ko05032), and "proteasome" (ko03050).The difference in fat intake does affect the expression of gut microbiota, but further exploration is needed to investigate the relationship with dietary habits and the impact of different bacterial expressions on prediabetes. Keywords - Gut Microbiota, Prediabetes, Fat.