Paper Title
MICROSCOPIC STUDY OF MORPHOLOGICAL CHANGES OF THE ERYTHROCYTE-BASED DRUG DELIVERY SYSTEMS.

Abstract
Abstract - Surgical purulent diseases affect millions of people every year in all countries of the world. Increasing the antibacterial effectiveness of antibiotics by their targeted delivery is a very promising direction. Autologous blood cells are increasingly being used for targeted drug delivery due to their immunological compatibility with the human host organism. This paper presents obtained data on the microscopic examination of morphological changes in erythrocytes at each stage of the inclusion of the drugfor targeted delivery. Experimental results showed a positive correlation of morphological changes in erythrocytes with changes in osmotic pressure of the extracellular fluid. The data obtained demonstrated the possibility of creating drug delivery systems based on erythrocytes and the characteristic morpho functional and structural features of the loading procedure by the method of hypo-osmotic hemolysis. Keywords - Targeted Drug Delivery; Drug-loaded RBCs, Hypo-osmotic Drug Encapsulation Techniques; Scanning Electron Microscopy; Transmission Electron Microscopy; Resealed Erythrocytes.