Paper Title
SAFETY AND EFFICACY OF AN ATTENUATED LIVE VACCINE AND AN INACTIVATED VACCINE AGAINST PESTE DES PETITS RUMINANTS INFECTION IN GOATS

Abstract
Abstract - Peste des petits ruminants (PPR), a viral disease that mainly affects small ruminants, causes significant economic losses to the livestock industry in developing countries. Here, we evaluated the vaccine safety and immunization efficacy in goats of a live attenuated PPR vaccine andof an inactivated PPR vaccine, bothof which are based on the PPRV Nigeria 75/1 strain. Various doses of these PPR vaccines were administered to different groups of goats (124 goats, aged 4–12 months, divided randomly into 24 groups with five goats per group and four negative controls) in Kazakhstan, and the PPRV-specific antibodies induced by these vaccines were evaluated on days 21 and 28 post-vaccination using the serum neutralization tests. Goats vaccinated with 3, 2, or 1 mL of the inactivated vaccine and goats vaccinated with 104, 103, or 102 TCID50 of the attenuated vaccine were all protected after challenge with the virulent PPRV Kentau strain. None of the goats showed adverse reactions after immunization with the vaccines, except for those administered with 3 mL of the inactivated PPRV vaccine. These results indicate that both the attenuated and inactivated vaccines based on PPRV Nigeria 75/1 are safe and have high immune efficacies. Keywords - PPR; attenuated; Inactivated; Vaccine; Goat