Paper Title
ANTIPROLIFERATIVE EFFECT OF CLITORIATERNATEA ETHANOLIC EXTRACT AGAINST COLORECTAL, BREAST, AND MEDULLARY THYROID CANCER CELL LINES

Abstract
Abstract - Clitoria ternatea is a native plant with medicinal and nutritive significance in Asia.The goalof this work was to examine the antiproliferative role of Clitoria ternatea against colorectal (HCT116),breast(MCF-7),andthyroid(TT)cancercelllinesatcellularandmolecularlevels.Aphytochemicalanalysis, the cytotoxic effect, an apoptotic induction cell cycle analysis, and the expression level ofGAX, DIABLO, and NAIP1 genes were assessed. The plant extract exhibited a clear cytotoxic actionagainst the utilized cancer cell lines via a low IC50, foremost by means of cell cycle arrest at thepre-G0, G1, and S phases associated with an apoptotic induction. An apparent raise in the mRNAlevels of GAX and DIABLO and a concomitant decrease in the NAIP1 mRNA level were observed inthe used cancer cells treated with the IC50 of the plant extract. This study concluded that an ethanolic extract of Clitoriaternateainducedap optotic cell death, suggestingthatitcouldpossiblybeutilizedasanewsourceofanapoptosis-inducinganticanceragentforcolon,breast,andmedullarythyroidcancercelllinetreatmentswithfurtherdetailedstudies. Keywords - Clitoriaternatea; colorectal;Breast;Medullarythyroidcancer;Cellcycle;Anticancer