INTRAVENOUSLY INJECTED CDTE QUANTUM DOTS EXCRETED THROUGH ENTEROHEPATIC PATHWAY AND CAUSEDGUTTOXICITY
Abstract - CdTe quantum dots have great potential in clinical diagnostic imaging applications because of their excellent fluorescence properties.Because it contains the heavy metal cadmium, its toxicity to the human body has been concerned. However, few studies have investigated its possible toxicity based on its distribution and excretion behavior in the body. In this study, 12.5nmol/g quantum dots were injected intravenously into mice to observe their distribution and excretion behavior in vivo, followingexplored their possible toxic effects on intestine. The traditional view is that exogenous substances injected intravenously are excreted mainly through urine, but our results surprisingly found that quantum dots were excreted mainly through the enterohepatic pathway due to their increased size in vivo and caused toxic damage to the intestine. This study indicates the unique excretion behavior and thepotentialtoxictarget organ of gutfor quantum dots.
Keywords - Nanotoxicity; Gut toxicity; ADME; CdTe quantum dots; Excretion