Antimicrobial Peptides: Basic Facts and Prospective As An Alternative to Antibiotics
The availability of complete genome sequences and development of information technology have provided a greater opportunity for peptide based drug designing. The field of structure based drug designing is a rapidly growing area and the exposition of genomic, proteomic and structural information has provided new targets and opportunities for drug lead discovery. In the meat industry, the use of antibiotics as growth enhancers is a common practice and is reported that out of total , globally 50% of the antibiotic is used to promote growth. Wide spread and some time indiscriminate use of antibiotics has been accompanied by the emergence of microorganism that are resistant to these agents. Antibiotic resistance has been posing increasingly serious concern to the public, health specialist and animal food producers. To overcome antibiotics resistance and to retain consumer confidence in a safe food supply, health specialist and food animal producers are searching for alternative, yet effective means of preventing and treating emerging and re-emerging diseases. Thus, new approaches to the problem of antimicrobial resistance and development of novel classes of antimicrobial agents with less likelihood to gain resistance are needed. Antimicrobial peptide also known as host defense peptides are prevalent throughout the nature as a part of the intrinsic defenses of most organisms and have been proposed as a blueprint for the design of novel antimicrobial agents.
Keywords - Antimicrobial Peptides, Antibiotic resistance, Novel antimicrobial agents, host Defense Peptides.