Paper Title
The Association Between Ifnar2 and Dpp9 Genessingle Nucleotide Polymorphisms Frequency with Covid-19 Severity In Iranian Patients

Abstract
SARS-CoV-2, a single-stranded RNA betacoronavirus causes the global outbreak of coronavirus disease 2019 (COVID-19) which emergedrapidly. This pandemic has raised several clinical and scientific concern. Genetic factors can contribute to pathogenesis and disease susceptibility.There are single nucleotide polymorphisms (SNPs) in many of the genes in immune system that affect expression of specific genes or functions of some proteins related to immune responses against viral infections.In this study, we analyzed the impact of polymorphism in the interferon alpha and beta receptor subunit 2(IFNAR2) and Dipeptidyl Peptidase 9 (Dpp9) genes and clinical parameters on the susceptibility and resistance to Coronavirus disease (COVID-19). Methods - A total of330- SARS-CoV-2 positive patients (188survivors and 142non survivors) were included in this study.All single-nucleotide polymorphisms (SNPs) onIFNAR2 (rs2236757) and Dpp9 (rs2109069) were genotyped by the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method. Results - In survivor patients, the frequency of the favourable genotypes of IFNAR2SNP (rs2236757GC) was significantly higher than in nonsurvivor patients, and also Dpp9 (rs2109069AT) genotype were associated with the severity of COVID-19 infection. Conclusions - This study demonstrated that the severity of COVID- 19 patients was strongly associated with clinical parameters and unfavourable IFNAR2, Dpp9 SNPgenotypes. In order to establish the relationship between host genetic factors and the severity of COVID-19 infection, further studies are needed in multiple parts of the world. Keywords - SARS-Cov-2, COVID-19, Interferon Alpha and Beta Receptor Subunit 2, Dipeptidyl Peptidase 9, Single-Nucleotide Polymorphisms