Green Synthesis of Novel Chalcone Derived Pyrazolo [1,5-A]Pyrimidines as Potential Anti-Breast Cancer Against Mcf-7 Cell Line Utilizing Modified Polystyrene Polymer Under Microwave Irradiation
In this work, reformulated polystyrene has been used as a solid basic catalyst to synthesize novel pyrazolo[1,5-a]pyrimidine derivatives under microwave irradiation. A simple green protocol has been developed for the synthesis of potential therapeutic agents for the treatment of breast cancer against the MCF-7 cancer cell line. Using modified polystyrene catalysts, excellent product yields (90-96%) of pyrazolo [1,5-a]pyrimidine derivatives were obtained. SEM, FT-IR, and basicity measurements were used to characterize the catalysts. Microwave irradiation enhanced the catalytic performance of modified polystyrene catalysts. Furthermore, the modified catalyst showed high sustainability, which can be easily removed from the reaction system and reused up to five times without significant loss of activity. An investigation of the mechanism of the reaction was conducted using the 2D NMR technique, NOESY Experiment. The general structure of the novel compounds is given as
Keywords - Chalcone, Pyrazolo[1,5-A] Pyrimidine Derivatives, Microwave Irradiation, Modified Polystyrene Catalyst, NOESY Experiment.