Paper Title
Multifunctional Nanoplatform Based on Sunitinib for Synergistic Phototherapy and Molecular Targeted Therapy of Hepatocellular Carcinoma

Abstract
Hepatocellular carcinoma (HCC) is a tumor that seriously endangers hu-man health and has an extremely low five-year survival rate due to its difficulty in early diagnosis and insensitivity to radiotherapy and chemo-therapy. It is indispensable to explore novel therapeutical strategies to improve therapeutic efficiency of HCC. Herein, we devised a novel multifunctional nanoplatform (SCF NPs) with an amphiphilic polymer (Ce6-PEG2000-FA) and a multi-target tyrosine kinase inhibitors (sunitinib). SCF NPs showed superior therapeutical efficiency for HCC because of the synergetic effect of molecular targeted therapy and phototherapy. The Ce6-PEG2000-FA not only served as a nano carrier with excellent biocompatibility but also can act as a therapeutic reagent for photo thermal therapy (PTT) and photodynamic therapy (PDT). Furthermore, the folic acid group of Ce6-PEG2000-FA can enhance the active targeting performance of SCF NPs. As a multi-targeted tyrosine kinase inhibitor, sunitinib in SCF NPs can play a role in molecular targeted therapies, including tumor growth inhibition and anti-angiogenesis. In vivo experiments, SCF NPs showed multi-mode imaging capabilities, which can be used for tumorous diagnosis and intra operative navigation. Meanwhile, SCF NPs showed out-standing synergetic tumor inhibition ability. Tumors of SCF NPs group with laser radiation were eradicated without any recrudescence after 14 days treatment. Such theranostic nanoparticles offer a novel therapeutic tactic for HCC. Keywords - Multifunctional nanoplatform, Sunitinib, Photodynamic therapy, Photo-thermal therapy, Hepatocellular Carcinoma.