Paper Title
Effects of a 12-week Moderate-Intensity Exercise Training on Cognition and Memory in Aged Hyperlipidemia Zebrafish: An Analysis of Active Avoidance Behavior

Substantial evidences have indicated that the intake of high-fat diets in the elderly negatively correlated with learning and memory. Comprehensive studies have demonstrated that moderate-intensity exercise improve learning and memory function. Existing researches reveal that both aged zebrafish and aged humans has the same learning and memory impairment mechanism as hyperlipidemia. The zebrafish has apparent advantage as a model to study hyperlipidemia in the elderly. For example, they are highly fertile and cheap. The objective of this study was to investigate the effect of moderate intensity exercise training on memory and learning function in old zebrafish with hyperlipidemia. The old (24-26 months old) hyperlipidemic zebrafish used in this study were AB wild type. The flow rate of the exercise group was 50% of the critical swimming speed. Low-load exercise group (LW group) exercised 30 min/d, 5 d/wk; high-load exercise group (HW group) exercised 60 min/d, 5 d/wk. Each fish performed the active avoidance paradigm test after 12-wk training. Results show that the average number of trials of the long-term memory of HW group was less than that of control-nonexercised group. We conclude that the hyperlipidemia augments the long-term memory capacity after a 12-wk moderate-intensity exercise training (50 % critical swimming speed, 5 h/wk). Keywords - Hyperlipidemia, Memory, Moderate Exercise, Swimming.