Paper Title
Heat Shock Protein (HSP 83) of Leishmania Donovani A Potential Drug Target

Abstract
Leishmania donovani (a protozoan parasite) poses a serious health threat on human populationsin large parts of the world. Few antileishmanial drugs have been developed, while the drug-resistance problem is also increasing. There is thus a pressingneed to develop new effective antileishmanial. Emerging evidence indicates that the HSP83 could be proved as a potent lead molecule for drug targeting. In the search for effective antileishmanial drug target here, a three-dimensional (3-D) model for Leishmania donovani HSP83 was built using homologymodeling. The model was validated by PROCHECK and Ramachandran plot. Further the 3-D model of HSP83 was analyzed using in silico approach. Through Ramachandran plot analysis it was found that the portion residues falling into the most favored was 68.4%. This is thefirst study dealing with the modeling of L. donovani HSP83. Earlier, few researchers have identified and reported HSP83 as a potent drug target through mass spectrometry based proteomics study. The 3-D model could prove usefulin further functional characterization of this protein. The predicted model allows initial inferences about the unexplored 3-D structure of the HSP83 and may be further used in rational design of molecules for structure-function studies because it was reported as a potent drug target for antileishmanial drug discovery. The predicted 3-D model of the L. donovani HSP83 will be very useful in wet laboratory for drug target study. Keywords - Leishmania Donovani, Heat Shock Protein 83, Homology Modeling, Ramachandran Plot, 3-D Model.