Paper Title
Can the Proinflammatory Cytokines TNF-α and IL-6 Act as Biomarkers of Autism Spectrum Disorder? A Literature Review

Abstract
WHO reports that out of 160 children, one of them is Autism Spectrum Disorders (ASD). Experts estimate that the cause of autism is heavy metals. This review aims to see the progress of research on the potential use of IL-6 and TNF- cytokines as ASD biomarkers. Methods: This review uses sources from the Pub med and Science Direct databases. The keywords used were IL-6 AND TNF-α AND (Autism OR Autism Spectrum Disorder OR ASD). At the research identification stage, 63 studies were obtained, after screening, 6 studies were found that met the requirements for review. Results: Some of the included studies showed differences in the expression levels of IL-6 and TNF in ASD children and controls, although several other studies showed different things. Pro inflammatory cytokines such as IL-6 and TNF-α have been shown to increase in the brains of ASD children, although the mechanism is not yet understood. Conclusions: Despite inconsistent findings, some evidence suggests increased plasma expression levels of pro-inflammatory cytokines including IL-6 and TNF-. More in-depth and integrated research is needed to prove that IL-6 and TNF-α have the potential to be biomarkers of ASD. Keyword - IL-6, TNF-α, Autism Spectrum Disorder.