Paper Title
Synthesis of 3-(3,5-Dimethyl-2-(1,8-Naphthyridin-7-Yl)Phenyl)-1,3,5-Triazinan-2-Ones and 3-(3,5-Dimethyl-2-(1,8-Naphthyridin-7-Yl)Phenyl)-1,3,5-Oxadiazinan-4-Ones as Antibacterial Agents

Abstract
The derivatives of naphthyridines have shown anti bacterial, antifungal and carcinogenic activity. In recent years, research on derivatives of 1,8-naphthyridine has been intensive because these compounds show a wide range of biological activities. Nalidixic acid, for example, possesses strong antibacterial activity and used mainly for the treatment of urinary tract infections with gram negative pathogens. Naphthyridine derivatives react with adenosine receptors of sub types A1 and A2A. 3,5-Dimethyl-2-(1,8-naphthyridin-7-yl)benzenamine (1) reacts with isocyanates to form 1-(3,5-dimethyl-2-(1,8-naphthyridin-7-yl)phenyl)ureas (2a-e). Compound (2a-e) are converted into different 3-(3,5-dimethyl-2-(1,8-naphthyridin-7-yl)phenyl)-1,3,5-triazinan-2-ones (3a-j) by the reaction of urea derivatives (2a-e) and amines in EtOH in presence of TEA. Oxadiazinan-4-ones (4a-e) are obtained by the reaction of the urea derivative of naphthyridine (2a-e) with formaldehyde in EtOH. Urea derivatives (2a-e) are also converted to coreesponding isocyanates (5a) by the treatment of 2a-e with triphosgene in DCM.