Paper Title
A Review of the RMO-Responsive Poly(Nisopropylacrylamide) - Based Polymers with Tuneable Lower Critical Solution Temperature

Abstract
For more than a half-century, the potential of thermo-responsive polymers has been investigated, resulting in a never-ending struggle to advance knowledge in drug delivery research. Lower critical solution temperature (LCST) is a critical physical parameter for evaluating the performance and effectiveness of a thermo-responsive polymer in drug delivery diligence. Understanding thermo-responsive mechanisms and differentiating between LCST and upper critical solution temperature (UCST) systems is therefore critical in understanding how LCST behaviour can be tuned for a specific drug delivery application. The review summarizes and critically discusses recent studies on tuned LCST behaviour using various methods. The review's point of view emphasized a sampling of the inventive research on Poly(N-is opropylacrylamide), PNIPAA m-based thermo-responsive polymers. The review anticipates that a single step irradiation polymerization process at room temperature that does not involve chemical cross-linkers, accelerants, surfactants, or organic solvent will be advantageous. Keywords - Smart Polymers, Stimuli-Responsive Polymers, Thermo-Responsive Nanogels, Lower Critical Solution Temperature