Paper Title
Evaluation of Hybrid Coating Materials as Drug Carriers

Abstract
Purpose: The rapid development of materials engineering enables the creation of multifunctional materials with potential for medical applications. Ceramic-polymer composite materials are the best biomaterials for bone tissue regeneration. Moreover, the unique properties of polymers allow their additional modification and use as a carrier of active substance for targeted therapy. Methods: In the presented studies, the rate of drug release from coating polymeric and composite materials was determined. The following were used to develop the materials; two synthetic, bio-safe polymers (polyvinylpyr-rolidone (PVP) and polyethylene glycol (PEG)), collagen (COL), and hydroxyapatite (HAp). Materials were enriched with clindamycin and applied to 3D printed polylactide plates. Results: Using the HPLC technique, the rate of drug release was determined. It was observed that the drug was released faster from the polymer matrix than from the drug-modified HAp suspended in the continuous phase. For composite materials, similar values were observed for both the coating where clindamycin was in the polymer and the coating where clindamycin was in the polymer as well as the ceramic. Conclusion: Based on the results, it was confirmed that the composition of the material affects the amount of drug released over time. It was also observed that HAp grains limit the release of the active substance into the incubation fluid. Acknowledgement: The “Multifunctional biologically active composites for applications in bone regenerative medicine” project is carried out within the TEAM-NET program of the Foundation for Polish Science financed by the European Union under the European Regional Development Fund. This research was funded by Foundation for Polish Science, grant number POIR.04.04.00-00-16D7/18. Keywords - Composites, Coatings, Active Substances, Regenerative Medicine