Paper Title
Physicochemical and Mechanical Evaluation of Composite Coatings for Bone Tissue Regeneration

Abstract
Purpose: The multi functionality of biomaterials is a feature that ensures their long term performance. For implant coating materials designed for bone regeneration, not only biocompatibility but also bioactivity is important. This feature, ensures bonding to the natural tissues surrounding the implant, and thus eliminates the risk of displacement or loosening. Methods: In this study, novel composite coatings materials based on polyethylene glycol (PEG) and poly vinyl pyrrolidone (PVP) containing collagen and glutathione for bone regeneration were developed. The materials were subjected to mechanical and physiochemical analysis. It is important to mention that, the developed biomaterials have great potential due to the high biological value of the components used in their synthesis, which promote osteogenesis. Results: Incubation studies were carried out in fluids such as PBS or SBF. The pH value was measured and sorption capacity was determined to identify the potential for use as a drug carrier. The stability of the materials under these conditions was demonstrated. Tensile strength and hardness of the materials were also measured. The hardness was proven to be determined mainly by the coated material rather than the coating. Conclusion: The results obtained indicate the great potential of the developed coating materials. Research is currently underway to modification with the drug to impart additional functions. ased on the results, it was confirmed that the composition of the material affects the amount of drug released over time. It was also observed that HAp grains limit the release of the active substance into the incubation fluid. Acknowledgement: The “Multifunctional biologically active composites for applications in bone regenerative medicine” project is carried out within the TEAM-NET program of the Foundation for Polish Science financed by the European Union under the European Regional Development Fund. This research was funded by Foundation for Polish Science, grant number POIR.04.04.00-00-16D7/18. Keywords - Composites, Coatings, Regenerative Medicine, Hydroxyapatite, Bones