Paper Title
Fecal Microbiota Transplantation Meliorates Bone Loss in the Mice Mimicking Postmenopausal Osteoporosis: Involvement of Gut Microbiota-Bone Axis

Abstract
As an indispensable part of osteoporosis (OP), bone health and postmenopausal osteoporosis (PMOP) of middle-aged and elderly women is of particular concern. The accumulating evidence suggests that gut microbiota (GM) dysbiosis is involved in pathogenesis and clinical manifestations of PMOP. In this study, our data showed that fecal microbiota transplantation (FMT) could reshape the status of GM and ameliorate the bone loss in mice with ovariectomy (OVX)-induced OP. The relevant mechanism was to inhibit the excessive osteoclastogenesis by correcting the imbalance of GM, optimizing the intestinal permeability, and suppressing the release of pro-osteoclastogenic cytokines. During this process, blood circulation also provided a bridge between pro-osteoclastogenic cytokines, GM and bone. The strong point of our study was to explore crosstalk effects based on GM-bone axis in PMOP, and analyzed the differences and changes at different levels of the mice in each group before and after FMT treatment by combining the 16S rRNA sequencing and metabolomics. Hence, on the basis of this, FMT may be an alternative option to serve as a promising candidate for the prevention and treatment of PMOP in the future. Keywords - Fecal Microbiota Transplantation, Osteoporosis, Gut Microbiota, Short Chain Fatty Acids.