Paper Title
Improving DDI Prediction Performance of Node2vec Embedding using Graph Neural Network Based Models

Abstract
A drug-drug interaction (DDI) is a reaction between two or more drugs that can reduce or increase the reaction of a medicine synergistically or cause adverse side effects.DDI detection, therefore, is an important objective in patient safety and pharmaceutical industry.Many researchers try to predict the DDI of unknown drugs by training the known DDI data in-silico approaches. In-silico approaches can be categorized into three groups: knowledge-based, similarity-based, and graph-based. Among them, graph-basedapproachesare known to haveachieved great performance by casting DDI prediction as a link prediction problem on DDI graphs. In this paper, we explore how we can improve DDI prediction performance of the embedding learning methodnode2vec[6] using representation learning algorithms of graph neural networks (GNNs). We first created and trainednode2vec model toobtain initial drug features; then we usedthreeGNN based models to improve the learned node2vec drug embedding; finally, we used four different classifiersto implement link prediction, which is DDI prediction. Our experimental results showed that allfour classifiers performance were improved using GNN learned embedding. Keywords - Classifiers, Drug-drug Interactions, Drug-drug Interaction Prediction, Embedding Learning, Graphical Neural Networks, Node2vec