Paper Title
Nutraceuticals Importance in COVID-19: What is the Role of Resveratrol?

Since COVID-19 has affected global public health there has been an urgency to find a solution to both limit the infections and the aggressiveness of the disease once affected.The main characteristic of this infection is represented by a strong alteration of the immune system which, day by day, increases the risk of mortality consequently to a multiorgan dysfunction.Due to the fact that the nutritional profile can influence the patient’s immunity we focus our interest in resveratrol, a polyphenolic compoundknown for its immunomodulating and anti-inflammatory properties.So we reviewed all the informations concerning the different roles of resveratrol in COVID-19 pathophysiology using PubMed and Scopus as main databases. Interestingly we find out that resveratrol may exert its role through different mechanisms: in fact it has antiviral activity inhibiting virus entrance in cells and viral replication; resveratrol also improves autophagy and decreases pro-inflammatory agents expression acting as an anti-inflammatory agent; it regulates immune cell response and pro-inflmmatory cytokines and prevents the onset of thrombotic events that usually occur in COVID-19 patients. Keywords - COVID-19, Resveratrol, Immune System, Inflammation. Abbreviations - severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2); resveratrol (RES); angiotensin-converting enzyme 2 (ACE2);angiotensin II (AngII); srtuin 1 (SIRT1); cyclooxygenase (COX); tumor necrosis factor (TNF); interleukin (IL); nuclear factor erythroid 2 (Nrf2); 5′ AMP-activated Protein Kinase (AMPK);mammalian target of rapamycin complex 1(mTORC1)