Paper Title
Correlation Between D Dimer and CT Severity Score In Middle Aged Young Adults With Covid 19 Pneumonia: A Retrospective Study

Abstract
Aim: To correlate d dimer and CT severity score in Middle Aged Young Adults with COVID 19pneumonia. Material and method: The present retrospective study was conducted in the department of Medicine at Rural Medicine College, Loni. The study comprised of 108 subjects reported Covid positive during the study period (January-August 2021). Out of 108, 40 young adults having age of 30-40 years with no co-morbidities were selected. The severity of COVID-19 was defined according to WHO clinical management guidance of COVID-19. COVID-19 infection was confirmed by real-time reverse transcription polymerase chain reaction (RT-PCR) assay from nasopharynx swab samples. Pneumonia was confirmed by computed tomography (CT) examination and coagulation test completed within 12 h after admission were enrolled. Coagulation tests, which fibrinogen (Fib) and D-dimer were performed. CT score was categorized into mild grade (0-7), moderate grade (8–16) and an advanced grade (17–25 points). Results: The mean age of males and females was 38.52±5.34 and 35.67±3.22 years respectively, with an overall age of 37.79±4.58 years. Mean D-dimer level was 0.54±0.09, 0.91±0.22 and 1.96±0.47 μg/ml among subjects having mild, moderate and severe CT score respectively. Hence d-dimer increases along with CT severity score. According to multivariate analysis, higher D-dimer (OR: 3.61, P<0.01) was significantly associated with CT severity score. Conclusion: Based on our findings in which the D-dimer level's time point was matched to the time of CT scan, we have reasons to speculate that the D-dimer level may predict the severity of inflammation prior to coagulopathy/thrombosis. Keywords - COVID 19 Pneumonia, CORONAVIRUS, D-DIMER, Relation, CT Severity Score.