Paper Title
An Advanced Hybrid Electrochemical Sensing Platform for Identification CRP Concentration In Neonates During Neonatal Septicaemia

Neonatal septicemia (NS) is the leading cause of neonatal deaths across the globe. NS is caused by various fungi, viruses, and bacteria.The detection of NS is a very complex process due to its similar sign and symptoms as that of normal infection. Presently, the methods available are very tedious, time-consuming, and expensive. Therefore, there is a need to develop such platforms that can overcome these limitations. Biosensor development can serve this purpose very effectively as they are miniaturized therefore no specific or large infrastructure is required, low-cost development, provide rapid results, and are highly specific. This work represents the assembling of a sensing platform on the surface of a screen-printed electrode. In this work, a hybrid electrochemical biosensor was developed for identifying the level of C-reactive protein (CRP) a neonatal sepsis biomarker. The biosensor was assembled on the surface of a screen-printed electrode (SPE) modified with molybdenum disulfide nanosheets (MoS2NSs). Further, the synthesized MIP for CRP was electrodeposited on the surface of MoS2NSs modified electrode. The electrode response was examined in presence of anti-CRP using electrochemical technique. This developed sensing platform exhibit a wide concentration range from 0.01 nM to 1 μM and a lower limit of detection (0.01 nM). Keywords - Nanomaterial’s; C-reactive protein; Neonatal septicaemia; Molecularly imprinted polymer