Paper Title
Downregulation of EGFR mRNA Might Light a Candle in Small Cell Lung Cancer Diagnosis

Abstract
Lung cancer is the most lethal cancer type among both sexes worldwide. Histologically, lung cancer has 2 different subtypes; small cell lung cancer (SCLC) and (NSCLC). The epidermal growth factor receptor (EGFR) is frequently upregulated in NSCLC. However, the EGFRmRNA expression pattern in SCLC is still elusive.The current study aimed to quantify the expression level of EGFR mRNA to provide a better diagnosis of SCLC. We have determined the EGFR mRNA expression level in carcinoma tissues of SCLC (n= 10) and their matched non-neoplastictissues.Quantitative real time-PCR results revealed a significant downregulation of EGFR expression level in SCLC compared to their corresponding healthy tissues(p < 0.001). Interestingly, Receiver operating characteristic (ROC) curve indicates that EGFR had a diagnostic accuracy with an area under the curve (AUC) of 0.93. Therefore, EGFR mRNA expression levelsemerge as a diagnostic marker for SCLC patients. Keywords - Epidermal Growth Factor Receptor (EGFR); Small-cell Lung Cancer (SCLC); Gene Expression level; Computed Tomography; Lung Cancer Diagnosis.