Synthesis of Camphor Hydrazone Bioactive Compound Derivatives using [Et3NH][HSO4] Ionic Liquid Catalyst
In this research paper, the camphor hydrazone derivative compound has been synthesized using camphor, hydrazine hydrate, and variations of aromatic aldehydes as precursors. The synthesis of camphor hydrazone compound derivatives can be increased the efficiency of its product formation time by adding a triethylammonium hydrogen sulfate or [Et3NH][HSO4] ionic liquid catalyst.The success of the formation of camphor hydrazone derivatives were characterized using FT-IR, UV-Visible spectrophotometer, and GC-MS. This study also tested the potential bioactivity of the camphor hydrazone derivatives compound as an antioxidant using the DPPH method. The strength of antioxidant activity expressed as IC50 values were evaluated. The IC50 values of derivative of compound 1 was 96,2 ppm, the derivative of compound 2 was 102,2 ppm, and the derivative of compound 3 was 306,5 ppm.
Keywords - Camphor, Hydrazone, [Et3NH][HSO4], Antioxidant.