Paper Title
Quinoline-Imidazole Hybrid Molecules Active Against Multidrug Resistant Escherichia Coli and Antibacterial Agents

Abstract
Escherichia coli infections, being a multidrug resistant, have produced a critical health threat universally. WHO has stratified Escherichia coli as high level priority II pathogen due to its increasing resistance to all the present chemotherapeutics. Therefore, discovery and development of new antibacterial agents is vital to address the multidrug resistant Escherichia coli infections. The understanding of the impact of the new antibacterial drug on the biological target gives us opportunities for further studies. Present article highlights on diverse aspects of drug design, structure activity relationships and mode of action of various new antibacterial agents and also covers the recent reports on new antibacterial agents with potent activity against multidrug resistant Escherichia coli. In this study, we synthesized a series of oxazole and their imidazole derivatives from quinoline aldehydes. The structures of all the synthesized compounds were elucidated by elemental and spectroscopic techniques. All the synthesized compounds were evaluated in vitro for their antibacterial activities. It reveals that introducing bromine at the C6 position of quinoline does not change the original interactions, but might have made a subtle change in binding conformation, resulting in an obvious improvement in activity. It was revealed that some synthesized derivatives show remarkable biological activity against both Escherichia coli species. It was revealed that some synthesized derivatives were exhibiting competent biological activity against both gram negative & gram positive bacterial species and fungal microorganisms. Keywords - Quinoline; Hippuric Acid; Diamines; Imidazole; Antibacterial Activity