Paper Title
Cellulose Membrane as a Potential Carrier for Controlled Delivery of The Topical Treatment for Periodontal Disease

Abstract
The present study aimed to determine the effectiveness of a cellulosic membrane as a carrier for the controlled release of an active formulation proposed by us for the topical treatment of periodontal disease. The spectrophotometric investigations allowed to follow up the releasing profile through the cellulosic membrane for melatonin, metronidazole, and tetracycline that were present in the topical treatment considered. It was shown that for metronidazole there is a continuously increased delivery after 48 hours of application of the treatment with the increase of the concentration, while for melatonin and tetracycline it was recorded a quasi-constant release from a concentration of 0.83 x 10-5 mol/L for melatonin and 0.60 x 10-4 mol/L for tetracycline. Keywords - Melatonin, Tetracycline, Metronidazole, Oral Pathology, Cellulosic Membrane