Paper Title
In Silico and In Vitro of Active Compounds From Cananga Odorata (Lam.) Against Staphylococcus aureus

Staphylococcus aureus is a significant pathogen causing infections, pneumonia, septicemia, gastroenteritis, endocarditis and meningitis with the use of beta-lactam drugs as a treatment option. Antibiotic resistance to S. aureus has become a growing health problem in many parts of the world. S. aureus was initially sensitive to penicillin but in the 1960s the strain of Methicillin-resistant Staphylococcus aureus (MRSA) emerged as a nosocomial infection. The acquisition of the mecA gene primarily results in resistance to S. aureus to methicillin. This gene encodes the production of affinity-reduced penicillin-binding protein 2a (PBP2a). From recent researches, ylang-ylang (Canangaodorata) flowers are used against tinea infections, fever, malaria, antiviral, etc. Flower juice of ylang-ylang can effectively prevent the growth of S. aureus. In the silicomethod with molecular tests carried out using PyRx-Autodock-Vina software to predict the interaction of five active compounds of ylang-ylang flower ethanol extract with PBP2a receptors. In an in vitro test, the effect of 97% of ylang-ylang flower ethanol extract was evaluated by absorbance results from a spectrophotometer. Based on a molecular docking test, it was found that five ylang-ylang active compounds have effects on the PBP2a receptor. From the results of in vitro tests, it was also found that 97% ethanol extract of ylang-ylang flowers had lower absorption. and bacterial density than water extractylang-ylang flowers and a control sample. On the other hand, 97% ethanol extract of C.odorataflowerscan be used as antibacterial drug. Keywords - Canangaodorata, Staphylococcus Aureus, Active Compounds