Effects of Regular Exercise on Cognition and Memory Function in Ageing Zebrafish: An Analysis of Active Avoidance Behavior
With increased age, adults may experience declines in memory and cognitive function. Although previous studies have extensively demonstrated exercise has been demonstrated to improve memory and cognitive function. Nevertheless, there has thus far been relatively little research into the correlation between moderate intensity exercise training and memory and cognitive function. In recent years, many studies have confirmed that zebrafish exhibit a decline in whole-organism performance and trainability with age. These findings closely resemble the senescence related declines in physical activity experienced by humans and mammalian aging models and therefore support the use of zebrafish as a model for human exercise and aging. The aim of this study was to develop the zebrafish model of moderate intensity exercise training to assess memory and cognitive function using active avoidance test. The results showed that old zebrafish after 8 weeks of moderate intensity exercise (50 % critical swimming speed, 30 min/d, 5 d/wk) can improve cognitive capacity.
Keywords - Aging, Cognition, Exercise, Moderate Intensity, Zebrafish