Paper Title
Myristica Fragrans as Medicine: A Systematic Review

Problem Statement: The fruit of myristica fragrans is the source of two commercial spices; nutmeg and mace, derived from its seed kernel and aril, respectively.For centuries it has been used primarily as a spice but recent studies have shown it to have many therapeutic effects and numerous health benefits.The purpose of this systematic review is to provide comprehensive evidence on myristica fragrans regarding its medicinal uses and therapeutic benefits. Methods: We conducted a systematic review according to the Preferred Reporting Items for Systematic reviews and Meta-Analysis (PRISMA) guidelines and protocol (PRISMA-P) statement. PubMed, Science Direct, Cinahl, Lilacs, Cochrane Central Register of Controlled Trials, and Cochrane Database of Systematic Reviews were systematically searched using the key words “myristica fragrans” and “nutmeg” until October 15, 2019. The evidence regarding the health benefits, medicinal uses, and disease causation of myristica fragranswere examined. Results: From the described search 837 articles were identified. One hundred and seventy six (176) studies were included in this systematic review. Numerous studies have shown myristica fragrans to be an effective antimicrobial, antioxidant, anti-inflammatory, antineoplastic, antidiabetic, anti-obesity, antidepressant, and anticonvulsant agent. In addition, it has shown to improve memory and reduce cholesterol levels. Conclusion: There is overwhelming evidence regarding the medicinal uses and therapeutic benefits of myristica fragrans. Health care providers should increasingly use myristica fragrans to treat and prevent diseases and to promote heath. Keywords - Myristica Fragrans, Nutmeg, Mace, Medicinal Spice, Treatment