Paper Title
Effect of Selected Chalcones on RBCs Membrane of both Infected and Uninfected RBCs

Chalcones are diaryl keton derivatives with broad distribution in botanical products and diverse biological activities. Their hydrophobicity may entitle them to produce their action through compromising the functional properties of membranous structures. In this experiment, the potential of six chalcone derivatives; namely; chalcone, 2’,4’-dihydroxychalcone, 2’,4’ dimethoxychalcone, 4’chlorochalcone, 4- isopropyl-4’-methylchalcone and 4’-methylthiochalcone to inhibit the plasmodial growth was screened using SYBRE green-1 based drug sensitivity assay In order to get some clues about their mode of action, their impact on sorbitol induced hemolysis of the parasitized cell (PRBCs) was screened. Furthermore, their antioxidant potential was tested in vitro and compared with its anti-plasmodium effect. In addition, their cytotoxicity against RBCs and mammalian cells were tested to exclude any potential toxicity against normal cells. Results show that all the mentioned chalcones have a limited action against Plasmodium falciparum K1. These actions were not related to their effect on RBCs membrane or to the parasite induced new permeation pathway. Further studies are required to elucidate their full mechanism of actions and if they can augment CQ action in vivo. Keywords - Chalcone, Chloroquine, Hemolysis, Plasmodium Falciparum and SYBR Green-I.