Development of Wound Healing Formulation using Honey and Whey Protein
Wound healing is a complex biological process, which is severely impaired in disease conditions such as diabetes, obesity, venous or arterial disease, immune-suppressants treatment and is also affected due to old age, smoking and bacterial infection. Skin plays an essential role in our bodies, it protect from attack by foreign organisms or entry of noxious substances. Various microorganisms colonize the skin such as: bacteria, fungi, viruses and mites. Injury to skin and also delay in wound healing process can make wound sites more susceptible to microbial infection. In this research, the potent antimicrobial activity of honey and wound healing property of whey protein has been exploited to prepare a novel wound healing formulation. Honey has been used for thousands of years for treatment of cold, flu, burn and other injuries, liver and gastrointestinal diseases. Honey has also been shown to possess potent anti-microbial activity against various microbes. Another component was used in this study is whey protein, which is a cocktail of various proteins fractionated during the manufacturing of cheese from bovine’s milk. Whey protein is a rich source for growth factors such as IGF-I, IGF-II, TGF beta, FGF, PDGF and EGF. Growth factors promote cell proliferation and differentiation and also play crucial role in tissue repair. Wound healing properties of growth factors present in the whey protein along with anti-microbial and wound healing activity of honey have been used to develop a novel and potent wound healing formulation for treating various wounds.
Keywords - Wound healing, Honey, Whey protein, Growth factors, Skin microbiome, Metagenomics, Antimicrobial activity.