Paper Title
Impact of Closed System Drug Transfer Device on Surface Contamination by Antineoplastic Drugs

Abstract
Health care workers who could come into contact with cytotoxic drugs may be at risk of harmful effects from antineoplastic drugs as a result of occupational exposure. This study was conducted to compare surface contamination to antineoplastic drugs before and after the implementation of CSTD- Tevadaptor®. Surface contamination was assessed by the wiping test using Bernerkit. Sample collection was done in two time points, before and after using Tevadaptor® for 5- fluorouracil, cyclophosphamide and gemcitabine preparation. The use of CSTD significantly reduced (by 94.5%) the surface contamination with 5-fluorouracil (p=0.043). When Tevadaptor® was used the contamination with cyclophosphamide was reduced by 96.8% to a level of 0.79 ng/cm2, d. A decrease of 42.5% (in median value) was also observed for gemcitabine following Tevadaptor use. The use of a CSTD (Tevadaptor®) reduced surface contamination of all tested antineoplastic molecules. Keywords - 5-Fluorouracil, Closed System Drug-Transfer Device, Cyclophosphamide, Gemcitabine, Tevadaptor®.