Paper Title
Voltammetric Disposable Screen-Printed Electrode Modified with a Schiff Base Ionophore for Fe (III) Detection in Blood Serum

Abstract
A potent electrochemical ionophore (SMS-2) based on a Schiff base has been used for the modification of a screen-printed electrode (SPE). The modified disposable electrode showed selectively for ferric ions detection in an aqueous medium. Electrochemical behavior of the proposed strip was characterized using cyclic voltammetry (CV) and differential pulse voltammetry (DPV). Incorporation of the ligand in the ink of the SPE enhanced the analytical performance of the electrode, and its surface modification was confirmed by SEM and EDX analysis. Shifting/quenching of the cathodic peak potential of the ionophore after binding with Fe (III) ions was used to detect and measure the ferric ion concentration. This sensor can identify Fe (III) in the detection range from 0.625 μM to 7.5 μM and limit of detection (LOD) was found to be 0.93 µM. The modified SPE can selectively detect ferric ions in the presence of many other interfering ions and has been successfully used to determine the Fe (III) content in blood serum samples. The metal–ionophore complex structure was optimized using DFT calculations to study the energetic of the metal–ionophore interactions. Keywords - Schiff Base Modified Screen Printed Electrode, Voltammetric Sensor, Differential Pulse Voltammetry, Density Functional Theory, Ferric Ion.