Paper Title
Molecular Modeling Contribution to The Search for Natural Selective Inhibitors of Cycloxygenase 2

Abstract
Cyclooxygenase (COX) is the key enzyme in the synthesis of prostaglandins from arachidonic acid whose metabolites are responsible for inflammatory processes, making Cycloxygenase a potential target for the treatment of inflammatory diseases, the effects adverse effects of these anti-inflammatories are related to inhibition of COX 1. The constitutive COX-1 encoded by a gene located on chromosome 9 is composed of 576 amino acids and is expressed in the majority of cells and tissues, such as the gastrointestinal tract, kidneys and platelets. The inducible COX-2 encoded by a gene carried on chromosome 1 is composed of 581 amino acids, the two iso forms COX1 and COX2 have a structural homology of 60%. Our work we are interested in molecules of natural origin that can inhibit the cox2 in a selective way, in this sense we carried out a study by molecular docking technique which consists of the study of interactions bioactive molecules-COX1 in comparison with COX2. Keywords - Natural Substances, COX1, COX2; Molecular Docking, Selectivity,