Paper Title
Synthesis, Characterisation Of New Derivatives With Benzimidazole-1, 2, 4-Triazole Scaffold And Their Antifungal Activities

Abstract
Invasive fungal infections have become an important factor in adversely affecting patients' living standards.Moreover, the resistance of organisms to drugs has made this problem even more critical.The structures of 8 novel benzimidazole-1,2,4-triazole compounds synthesized as antifungal agents were characterized by IR, 1H NMR, 13 CNMR and mass spectroscopy.The synthesized compounds were screened in vitro antifungal activity against C. albicans, C. krusei, C. parapsilopsis and C. glabrata. According to antifungal assay, compound 5cshowed the most promising antifungal activity with a MIC50 value of 1,56 ug/mL against Candida albicans and C. parapsilopsis. Index Terms: 1,2,4-triazole, Benzimidazole, Antifungal.