Paper Title
Antimicrobial Activity of Substituted Pyrazoles

Abstract
In the reaction of acetylacetone and benzoyl hydrazides in the presence of vinegar as catalysts and solvent, benzoyl-pyrazole derivatives were obtained, in moderate to high yield. The purity of synthetized compounds was verified using spectroscopic techniques NMR and IR. Synthetized compounds were tested for their in vitro antimicrobial activity. Among the tested substances chloro derivative 2jexpressed the most significant activity, on both, Gram positive bacteria and filamentous fungi. The same substance showed better antifungal activity than the positive control. Compounds 2d and 2m also had significant antifungal activity, close or better than the positive control (15.78-62.5 μg/mL). It is worth pointing out that Gram positive bacteria showed higher sensitivity than Gram negative bacteria, especially to compounds 2l, 2j, and 2k. Keywords - Benzoyl hydrazides, 1-Benzoyl-1H-pyrazole, Vinegar mediated synthesis, Antimicrobial activity.