Paper Title
Antifungal Activity of Neolignan Derivatives from Eusideroxylon Zwagery Against Pathogenic Fungus Microsporum Gypseum

Abstract
A research on antifungal activity of Neolignan derivatives from Eusideroxylon zwagery against pathogenic fungus Microsporum gypseum had been carried out. Eusiderin I, Compound B and Compound C were isolated from wood of Eusideroxylon zwagery. All three compounds are white crystals with melting point in such 99-100 oC, 110-112 oC, 98-99 oC, respectively. Eusiderin I, compound A and Compound B were characterized using UV spectroscopy and compared with previous data. Antifungal activity test was conducted with Microsporum gypseum using paper disc method. The antifungal activity test of Eusiderin I, Compound B and Compound C from Bulian wood (Eusideroxylon zwagery) to phatogen fungus of Microsporum gypseum showed that with three different concentrations (5, 10 and 15 ppm), Eusiderin I was a potent antifungal compared others because it had a strong activity in inhibiting the Microsporum gypseum growth. The 5 days incubation test result showed that 5 ppm Eusiderin I could inhibit the Microsporum gypseum colony growth. The 10 ppm Eusiderin I gave the most effective inhibition precentage because it could inhibit the Microsporum gypseum colony growth (= 93.9%). Based on this data, Eusiderin I can be indicated an antifungal candidate. Keywords - Eusideroxylon Zwagery, Microsporum Gypseum, Eusiderin, Compound B, Compound C, Antifungal